A year ago I finally stopped taking antimicrobials for SIBO after a solid year of trying hard to eradicate it with first prescription antibiotics, then herbals and diet. I never got a totally negative test last May but it was low enough that we all decided it was not worth trying to keep chasing down the last few points. After the Symposium in June I decided that maybe I would never test negative due to large amounts of m.smithii in the colon so changed tactics to work on my colon flora and ignore the SIBO.